Treatment patterns among Chronic users of immediate-release Oxycodone initiating treatment with extended-release Opioids
نویسندگان
چکیده
منابع مشابه
Tapentadol immediate release versus oxycodone immediate release for treatment of acute low back pain.
BACKGROUND Tapentadol has demonstrated analgesic efficacy across a range of pain conditions. OBJECTIVE In a head-to-head study of up to 10 days in duration, the analgesic efficacy and tolerability of tapentadol immediate release (IR) versus oxycodone IR using a flexible dosing regimen were compared in patients with acute low back pain (LBP) and associated radicular leg pain. STUDY DESIGN Ra...
متن کاملOxycodone DETERx®: A Novel Abuse-Deterrent, Extended-Release Analgesic Option for the Treatment of Patients with Chronic Pain
BACKGROUND Extended-release (ER) opioid analgesics are commonly used to provide safe and effective pain relief to treat pain severe enough to require around-the-clock, long-term dosing. These ER opioid formulations usually contain more drug per dosage unit than immediate-release (IR) agents, and therefore bring with them challenges related to both opioid abuse and misuse, often through manipula...
متن کاملTapentadol extended-release for treatment of chronic pain: a review
Tapentadol is a centrally acting analgesic with a dual mechanism of action of mu receptor agonism and norepinephrine reuptake inhibition. Tapentadol immediate-release is approved by the US Food and Drug Administration for the management of moderate-to-severe acute pain. It was developed to decrease the intolerability issue associated with opioids. Tapentadol extended-release has a 12-hour durat...
متن کاملRelative Bioavailability Study of an Abuse-Deterrent Formulation of Extended-Release Oxycodone with Sequestered Naltrexone (ALO-02) Versus Immediate-Release Oxycodone Tablets in Healthy Volunteers
Abbreviations: AE: Adverse Event; ALT: Alanine Aminotransferase; AUCinf: Area Under the Plasma Concentration-Time Profile from Time 0 to Infinity; AUClast: Area Under the Curve to the Last Quantifiable Concentration; BLQ: Below Lower Limit of Quantification; BMI: Body Mass Index; BP: Blood Pressure; C24: Concentration at 24 Hours Post Dose; Clast*: the Predicted Plasma Concentration at the Last...
متن کاملTreatment with prolonged-release oxycodone/naloxone improves pain relief and opioid-induced constipation compared with prolonged-release oxycodone in patients with chronic severe pain and laxative-refractory constipation.
PURPOSE Laxative-refractory opioid-induced constipation (OIC) is defined as OIC despite using 2 laxatives with a different mechanism of action (based on the Anatomical Therapeutic Chemical Classification System level 4 term [contact laxatives, osmotically acting laxatives, softeners/emollients, enemas, and others]). OIC has a significant impact on the treatment and quality of life of patients w...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2015
ISSN: 1098-3015
DOI: 10.1016/j.jval.2015.03.1762